Education:
Postdoctoral Researcher, Neurochemistry, Dept. of Chemistry and Dept. of Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, May 1995 to present, Advisors: Richard J. Bridges and Charles M. Thompson
Postdoctoral Researcher, Bioorganic Chemistry, University of California, Irvine, Irvine, CA 92717 October 1992 to March 1995, Advisor: A. Richard Chamberlin.
Ph.D. Chemistry, Colorado State University, Fort Collins, CO 80523, Completed September, 1992 , Advisor: Robert M. Williams. Dissertation Title: Studies Toward the Total Synthesis of the Fungal Metabolite Fusarin C.
B. S. Chemistry, New Mexico State University,
May 1986, Las Cruces, NM 88001, Advisor: Robert V. Hoffman.
Minor Physics.
Research Experience:
Postdoctoral Research Associate, University of Montana, Missoula, May 1995 - present.
Postdoctoral Research Associate, University of California, Irvine, October 1992 to March 1995.
Graduate Research Assistant, Colorado State University, June 1987 to September 1992.
Undergraduate Research Technician, New Mexico State University, December 1983 to July 1986.
Teaching Experience:
Overseeing Graduate Research, University of Montana, Fall 1995 through present, University of California, Irvine, Spring 1993 through Spring 1995.
Undergraduate Research Advising, University of Montana, Spring 1996, University of California, Irvine, Fall 1993 through Spring 1994, Colorado State University, Fall 1989 through Spring 1991.
Guest Lecterer Organic Chemistry (five lectures, ca. 200 students), Univeristy of Montana, Spring 1997 through Spring 1998.
Pharmacy Laboratory "Extraction of Caffeine from Tea", University of Montana, Spring 1997 and Spring 1998.
Guest Lecterer Graduate Level Synthetic Organic Chemistry, University of Montana, Spring 1996.
Graduate Teaching Assistant, Colorado State University, Organic Chemistry Laboratory, September 1986 to May 1987; Advance Organic Laboratory, Spring 1988; Spring 1990.
Publications:
Koch, Hans P.; Esslinger, C. Sean; Thompson, Charles M.; Chamberlin, A. R.; Bridges Richard J.; "Substrates and Nonsubstrates of the Na+-Dependent Synaptosomal Glutamate Transporter" J. Molecular Pharmacology (In preparation).
Esslinger, C. Sean; Carrigan, Christina N.; Koch, Hans, P.; Lovering, Frank E.; Blakely, Tracy N.; Ho, Sammy; Daily, William; Chamberllin, A. Richard; Bridges, Richard J.; Thompson, Charles M. "Inhibition of the Na+-dependent Synaptosomal Glutamate Transporter: The Effect of g-Acidic Group Substitution" J. Med. Chem. (In preparation).
Bartlett, R. D.; Esslinger, C. S.; Thompson, C. M.; Bridges, R. J. "Sustituted quinolines as inhibitors of l-glutamate transport into synaptic vesicles" Neuropharmacology 1998 (in press).
Esslinger, C. Sean; Koch, Hans P.; Kavanaugh, Michael P.; Philips, Dean P.; Chamberlin, A. Richard; Thompson, Charles M.; Bridges, Richard J.; ÒStructural Determinants of Substrates and Inhibitors: Probing Glutamate Transporters with Meso-2,4-Methano-2,4-Pyrrolidine Dicarboxylate" Bioorganic and Medicinal Chemistry Letters (accepted July 1998).
Esslinger, C. S., Bridges, J. R., Chamberlin, A. R. Inset picture,1994 cover of Bioorganic and Medicinal Chemistry Letters.
Williams, R. M.; Esslinger, C. S. "Synthesis of Tri-substituted Furans: Mild Ti(IV)-Mediated Couplings to Acetals. Construction of the Epoxy Hemi-amido Ketal of Fusarin C" Tetrahedron Lett. 1991, 32, 3635.
Hoffman, R. V.; Carr, C. S. "Regiospecific Synthesis of a-Arylsulfonoxy Ketones from Ketone Derivatives"Tetrahedron Lett. 1986, 27, 5811. (Applicant as Carr).
Hoffman, R. V.; Jankowski, B. C.; Carr, C. S. "The Reactions of a-Arylsulfonoxy Ketones with Nucleophiles" ibid. 1986, 51 , 130. (Applicant as Carr).
Hoffman, R. V.; Carr, C. S.; Jankowski, B. C.
"Synthesis of a-Arylsulfonoxy
Ketones from Ketone Derivatives" J. Org. Chem. 1985, 50,
5148. (Applicant as Carr).
Posters:
Esslinger, C. S.; Bartlett, R. D.; Carrigan, C.; Thompson, C. M.; Bridges, R. J. "Synthesis and Biological Activity of Quinolin Dicarboxylic Acids As Nonconventional Glutamate Analogues" Society for Neuroscience Meeting, November 1998.
Carrigan, C.; Esslinger, S.; Bartlett, R.; Thompson, C.; Bridges, R. "Glutamate analogs probing the glutamate vesicular transport site" American Chemical Society Meeting, August 1998.
Esslinger, C. S.; Bartlett, R. D.; Koch, H. P.; Patel, S. A.; Chamberlin, A. R.; Thompson, C. M.; Bridges, R. J. "Computer Based Molecular Modeling of Binding Site Pharmacophores in Three Distinct Glutamate Transport Systems" Society for Neuroscience Meeting, November 1997.
Koch, H. P.; Esslinger, C. S.; Hull, C. E.; Chamberlin, A. R.; Bridges, R. J. "Attenuation of an Injury Induced Efflux Through the High-Affinity Sodium-Dependent Glutamate Transporter in Cortical Synaptosomes" Society for Neuroscience Meeting, November 1997.
Bridges, R. J.; Kavanaugh, M. P.; Zerangue, N.; Koch, H.; Esslinger, S.; Humphrey, J.; Amara, S. G.; Chamberlin, A. R. ÒConformationally constrained inhibitors of the human glutamate transporters: differentiation of substrates and non-transportable blockersÓ Society for Neuroscience Meeting, November 1996.
Koch, H.P.; Esslinger, C. S.; Chamberlin, A. R.; Bridges, R. J. ÒA potent glutamate uptake inhibitor: L-trans--pyrrolidine-4-sulfono-2-carboxylateÓ Society for Neuroscience Meeting, November 1996.
Willis, C, L.; Esslinger, C. S.; Chamberlin, A. R.; Bridges, R. J. ÒPotentiation of L-Glutamate-induced neurotoxicity in vitro by inhibition of glutamate uptakeÓ Society for Neuroscience Meeting, November 1996.
Koch, H.; Lovering, F.; Esslinger, S.;
Chamberlin, A. R.; Bridges, R. J. ÒGlutamate uptake inhibitors;
differentiation of substrates and non-substratesÓ Society for Neuroscience
Meeting, November 1995.
Technical Skills:
Air and water sensitive reaction techniques; Amino
acid coupling techniques; Chromatography for isolation including column,
radial, and plate; Chromatography for analysis including HPLC, GC, GC/MS,
and TLC; Reverse-Phase HPLC of nonderivatized amino acids and small peptides;
NMR techniques including routine proton and carbon, 2-D, NOE, decoupling
and coupling; IR techniques including solution cell, KBr pellet, and NaCl
plate; UV/VIS operation; Computer techniques including CAS On-line, Microsoft
word processor and Chemwindows, advanced molecular modeling using the Tripos
and Quanta packages and familiarity with Macromodel and Insight II.
Awards:
National Institute of Health Postdoctoral Fellow, January 1997 to present.
American Heart Association Postdoctoral Fellow, July 1996 to December 1996.
Shell Graduate Fellow, September 1986 to May 1987
Darleen Hoffman Award for Outstanding Junior Chemistry Student, May 1985
Outstanding Freshman Chemistry Student, May 1983
Citizenship:
USA
References:
Dr. Charles M. Thompson
Dept. of Pharmaceutical Sciences
University of Montana
Missoula, MT 59812
(406) 243-4643
fax: (406) 243-4353
Home Page: http://www.umt.edu/medchem
e-mail: cmthomp@selway.umt.edu